The ADAM10 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ADAM10, kuz, and Kuzbanian. This antibody recognizes Human antigen. The ADAM10 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-:-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP)